Your account's default settings are shown here under Admin > Change Account Settings:
Trip Assist Information
This section of your account's settings is the agent alerting and Issue List set up. If you would like your agents to manage disruptions with an Issue List, select the Create Issues checkbox. Optionally, you can enter an Agent Alert Email if you'd like to notify your agents when an Issue is created. Don't forget to reprocess your itineraries if you add a new Agent Alert Email to your Trip Assist settings.
The Create Invalid Itinerary Issues and Require Opted in Traveler Profiles for Issue Creation are not used that often and are optional.
Trip Alert Information
This section is used for your traveler alerting. To turn on Traveler Alerts, select both the Traveler Alert and Opt-in checkboxes. If you use direct email or API delivery for messaging, please only select the Traveler Alert checkbox.