How can I quickly clear out my TripAssist "Open Issue List"?

A quick way to clear out multiple issues is to open them each in a new tab.  To do this you'll need to hold the CTRL key(on PC) or Apple/Command button(on Mac) and click on 'View' link for each of the issues.

Once this is done you can clear them out by marking them as 'expired', but don't move your cursor.  Instead, close the tab by holding the CTRL or Apple button while pressing the "W" key. This will close out the current tab and automatically open the next one on the list.

Here's the documentation related to the TripAssist portion of the console:
https://www.flightstats.com/itinerary/Help/TripAssistIssueList.jsp

Attached are PDF docs that help explain how to use tabbed browsing to clear out multiple issues quickly on a PC or a MAC.